Do I need a comma before IS?

Dear Tutors,

I hope that everybody is having a nice week-end.

I have a punctuation problem for this type of sentence:

One thing I have difficulty adapting to in English, is the pronunciation. 
But the first question, is "Where was she born?"

Do I need a comma before "is?" Am I right to end the second sentence with an interrogation mark? I think I don't need the interrogation mark if it is an indirect question.  But I don't know if it is a direct or an indirect question.

Thanks in advance,

SFB

Thanks pieanne

I'm going to review what I have written lately to correct my punctuation.

SFB

One thing I have difficulty adapting to in English, is the pronunciation. 
But the first question, is "Where was she born?"

I believe both commas [above] are wrong.  I'd write this:

One thing I have difficulty adapting to in English is the pronunciation. 
But the first question is, "Where was she born?"

I'm with Davkett too!

Hi Pieanne,

Although I have a tendency to misuse colons, I believe you are right to suggest that it would be a legitimate option here (to replace the second comma).