Yes. The main difference is in vocabulary but there are a few important grammatical differences:
1. BrE sometimes uses the present perfect while AmE use the past simple.
2. BrE uses have got while AmE tends to use have.
3. There are some differences inirregular verbs between AmE and BrE.
This is discussed at length here:
http://grammar-guide.com/details.asp?fIndex=45
Henry
Free-ESL