Hi,

I have two questions on this sentence.

Fear of physical and emotional damage is manageable when one's ears and heart hear the loving and strengthening voice of God, and the assurance that the global church will be there to embrace you.

Can I use a comma for the phrase 'the loving and strengthening voice' like 'the loving, strengthening voice'? Yes, but I prefer 'and' with no comma.

Can you say the comma between adjectives can be replaced with a comma ??? (do you mean 'relaced by 'and' ???)  in most situations (or in all situations??) when the word 'and' is used? Perhaps you are asking if you can say '. . . the loving, and strengthening voice gf God. . . . No, I wouldn't recommend that.  A comma after 'loving is unnecessary, and will make the reader hesitate and wonder if the subordinate 'when' clause consists of  when one's ears and heart hear the loving.

Do you think the comma before 'and the assurance' is placed mainly for the 'clarity' sake? It's there to help the reader find the end of the first half of the sentence. So, can I say a comma can be placed in a complex sentence (more or less arbitrarily) if I feel there is a danger of misreading? The purpose of commas is to help the reader understand the sentence easily. I would accept your statement if you said that the writer has some discretion in placing commas to help the reader understand his meaning. 

However, I definitely would not say that their use can be arbitrary. The writer has to consider the grammar of the sentence, or else commas will only confuse the reader.  

Do, you, see, what, I, mean?

Best wishes, Clive