Can you say like this?

A two-thousand people came toward me to ask me for some assistance.
I don't think so. Do you mean that 2000 people came toward you?
"a two-thousand people" is not right.
"the two thousand people" is right if you have already talked about the same two thousand people previously and you wish to refer to these same people again.

Teachers: We supply a list of EFL job vacancies
Yes, that's what I meant - two thousand people came toward me.

By the way, is it right to say "a two-thousand people" or "the two-thousand people"?
 CalifJim's reply was promoted to an answer.
Site Hint: Check out our list of pronunciation videos.