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I've heard the word Doc many times on TV, but when I looked up in Dictionary they told me that Doc is " A physician, dentist, or veterinarian.". However, I think Doc is something like Dude. So what is your take?
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Can you describe the times you've heard "Doc" on TV? Was it said by a grey rabbit who walks on two legs?
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Back in the 30's the famous cartoon character Bugs Bunny coined the expression, "What's up, doc?" It had nothing to do with medical degrees, but was more a casual sort of bravado, when Elmer Fudd was about to shoot him. The expression caught on, and is used in all sorts of situations. I agree that "What's up, dude?" is the same.

Best wishes, - A.

Edit. Sorry, GG, I didn't see your post.
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Yes, the expression was "What's up Doc"?
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Bugs Bunny was so universally known in American culture that many borrow that expression as a way of saying "Hi there. How are you? Anything new?"

You generally don't refer to other people as "Doc" (unless they are doctors) outside of that expression.
I know Doc Holliday was a dentist when he wasn't busy shooting people, but I'm not sure what Doc Severensen is a doctor of. - A.