+0
There is nothing wrong with them.
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There is something wrong with them.
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Anonymous Change to affirmative sentence. There is nothing wrong with them.
I'd say it's already affirmative. It affirms that there is nothing wrong with them.

CJ
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There is everything right with(/about) them.

It depends on the context, though, it would be safe to presume that nothing could be replaced by everything.
 CalifJim's reply was promoted to an answer.
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CalifJimI'd say it's already affirmative. It affirms that there is nothing wrong with them.
Interesting. I think this has more to do with the negative no-. We can also analyze both utterances as possible answers to a question:

Q: Is there anything wrong with them?
A1: Yes, there is something wrong with them.<---- affirmative
A2: No, there is nothing wrong with them. (There is not anything wrong with them.) <---- negative
ozzourtiInteresting.
I thought so, too. Emotion: smile
ozzourtiI think it has more to do with the negative no-.
Yes, of course. I was just commenting on how odd our terminology can be at times.

— When is an affirmation not an affirmation?
— When it contains a negative word in the context of a grammar discussion. Emotion: smile

CJ
Everything is not ok with them
Students: Are you brave enough to let our tutors analyse your pronunciation?
Everything is ok with them.