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Hello,
Is there a difference between 'call' and 'call up'?

1) I had to call him up and inform him

or

2) I had to call and inform him.

In general, is there a difference between the 2? Can 'up' be omitted at all times?

Likewise, can 'off' be omitted from 'drop off' as in "Can you please drop me (off) at the station?"

Can "off" be omitted all the time?

Thanks,
Prasanna
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sarnga11571) I had to call him up and inform him

or

2) I had to call and inform him.

In general, is there a difference between the 2?
No difference.
sarnga1157Can 'up' be omitted at all times?
With the meaning of calling by phone, yes. In general, no.

Her name is Lucy, but they call her Mimi. (not ..., *but they call her up Mimi.)
sarnga1157Likewise, can 'off' be omitted from 'drop off' as in "Can you please drop me (off) at the station?"

Can "off" be omitted all the time?
Same as above. With the same meaning, yes. In general, no.

While trying to cut the cake, I dropped the knife. (not ..., *I dropped the knife off.)

CJ
Comments  
There are small difference between English used in different countries. In the USA "call up" is almost never used.

I had to call him up. <<--- 99% of native USA speakers would not say this.
I had to call and inform him <---- correct, but it does not sound natural
I had to call and tell him <--- that is natural American English.

I hope this helps!

Rob Hewson