His patience is wearing thin.
His patience is running out.
His patience is pretty at an end.
He's at the end of his tether.
He can't take any more.

He's had enough
He's had it up to here
He's fed up
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It took a tolll on me

It took a tolll on me

This has a spelling error and a punctuation error.

how do I say this differently: when business alignment for a project is constant

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Coming to terms with the ending of therapy was highly personally meaningful and loaded with affective tensions, in ways that were not always shared with their therapist.