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I watched the OC, and listened a queation in it! What the help is going on? (am I spell right?) I want to ask is it same meaning of What happened? What's up?

I'm waiting for your reply! thanks a lot!
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I have no idea what OC is, but I presume you mean What the h e l l is going on, which has the same meaning as What is happening; however, h e l l is an intensifier of questionable propriety, and should not be used by non-native speakers unless they are adept in the language.
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Hello!

No, "what's up" is not impolite, but it's something you'll say to your friends. That's what Bugs Bunny always says to the little pig(I don't remember his name) "Hey, what's up, doc?"!
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Comments  
The OC is the tv programme ! I practice the listening through this tv programme! so, this sentence is learn from that!

Is native speaker will always say that?

And "What's up?" is it impolite ? Is just can say with our friends will be better?
 pieanne's reply was promoted to an answer.
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Dear friends,

«What's up?» is «what is the matter?»

«What's up!» is a greeting between friends.

I do not know if Bugs Bunny means the first or the second. Emotion: smile

With best wishes, Emotion: smile

Goldmund