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Please see the sentence below. My question is: After the word "ISSUE," should the verb be "IS" or "ARE" ? Your advice will be very much appreciated & I thank you.

Specifically, ther is no serious argument that production and financial information submitted to the bank by Mr. Smith regarding the wells at issue IS/ARE not relevant to the claims.
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Hello Wildcats1, welcome to English Forums.

Both might be correct:

1. There is no serious argument that production and financial information submitted to the bank is not relevant to the claims.

– here, the subject is "production and financial information submitted to the bank", i.e. a conglomerate of information about finance and information about production. So "is" is appropriate.

2. There is no serious argument that production and financial information submitted to the bank are not relevant to the claims.

– here, there are two subjects: "production", and "financial information submitted to the bank". So "are" is appropriate.

MrP
Comments  
The subject here is "production and financial information". Therefore, it should be "is" as information is a non-count or uncountable noun.
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Wildcats1Please see the sentence below. My question is: After the word "ISSUE," should the verb be "IS" or "ARE" ? Your advice will be very much appreciated & I thank you.

Specifically, ther is no serious argument that production and financial information submitted to the bank by Mr. Smith regarding the wells at issue IS/ARE not relevant to the claims.

IS
 MrPedantic's reply was promoted to an answer.