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The high court was the former gang leader's last chance to avoid death by injection after California Gov. Arnold Schwarzenegger denied him clemency earlier Monday and a federal appeals court panel rejected a request to stay his execution.

Do we need a comma in before of 'and' as ',and'. Please explain.
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It does not need a comma.
Would you be kind enough to explain the reason?
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RishonlyThe high court was the former gang leader's last chance to avoid death by injection after California Gov. Arnold Schwarzenegger denied him clemency earlier Monday and a federal appeals court panel rejected a request to stay his execution.

Do we need a comma [in before of] in front of 'and' as ',and'. Please explain.

Though a case could be made for it as a logical collocation, Rishonly, in English, we don't say <in before of>. Note the change I made, in red, above.

You don't need a comma before 'and'.

Point well noted, Katsudon. Thanks.
I do not think it needs a comma as this is just a long version of a simple construction. It's the same as

Taking a shortcut was the only way he could get to work on time after forgetting his tie and missing the bus.
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You're probably looking at two clauses separated by "and," and you want to place a comma before "and." An independent clause is one that can stand alone and MAKE SENSE.

The two clauses here are not actually INDEPENDENT clauses. Each clause needs the preposition "after" in order to complete its meaning. In other words, the second clause cannot stand by itself and still makes sense.

Ikia
Thanks, Ikia and Nona the brit.