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Is it possible to say as #1 in case Mr. and Mrs. Smith are Bob's parents?
Is it possible to say as #1 in case Mr. and Mrs. Smith are not Bob's parents?

#1. Mr. and Mrs. Smith loved having Bob with them.
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Yes, it would work in either case. If they are his parents, it would obviously be clearer to say 'having their son with them'.
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Comments  
Wow!
How clear!

Thanks!