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Today, people might think that the most important thing in their life is science. However, if you
look at it closely, you will find that people are actually influenced by many superstitions.

Can the 'it' here work as the reference of 'their life'?
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look at it closely

means

look at the matter/subject under discussion

which is whatever you figure it to be Emotion: smile,
perhaps the question "Which is the most important thing in peoples' lives?"
MH,

Actually, it's my composition. So, you don't think 'their life', or the reality, can be the referent?
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The composition is fine and clear to me.
Marius HancuThe composition is fine and clear to me.
Thank you, but my question is whether 'it' can work as the reference of 'their life'. I mean, this is supposed to be a translation of Japanese into English. And the original sentence is actually:

Today, people might think that the most important thing in their life is science. However, if you
look at the reality/their life as it is closely, you will find...

I'm wondering if it's possible to make it simpler by using 'it' instead here, without changing the meaning.
I agree with Marius's earlier comment that it stands for the matter/subject under discussion. I wouldn't take it as meaning if you look at their life. 'It' is often used in a very vague/general way.
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I think you could use here any of the:

look at the reality/their life as it is/this issue/this matter/it

depending on your needs in terms of variety and compactness.

But look at it has the idiomatic usage emphasized in the above.
Nona The BritI agree with Marius's earlier comment that it stands for the matter/subject under discussion.
Hmm...so the matter/subject under discussion here is going to be the fact that people might think that the most important thing in their life is science? Is that going to be the referent, nona?
Not really. It doesn't exactly directly refer to anything here. If you replace 'it' with 'things' you'll get the same meaning - a general look at 'something'.

It – indicating a point of view

Prounoun used to indicate feelings or a viewpoint on a particular situation eg 'It’s strange how things turn out'.
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