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I am fever and would like take a sick leave today. Billy appointed me at 16:00, would you please help follow with him? And I will follow with the ABC shipment at home.
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Just guessing:

I'm suffering from a high fever, and would like today off as a sick day (sick leave).

I have an appointment scheduled with Billy at 16:00, and would appreciate it if you could handle this for me.

I'll be able to take care of the ABC shipment from home.
Comments  
I caught a fever and would like to take today off,hope you will consider it.
I have a appointment with Billy at 16:00,would you do me a favor to handle it for me?thank you.
I will follow with the ABC shipment at home.
Pls be free to contact with me if anything urgent.