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with regards to
or
in regards to

what's the difference?
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They are both wrong. Use these: in regard to, with regard to or as regards.

In addition, the University of Victoria Writer's Guide adds this warning: '...Better still, avoid altogether [these phrases, which smack] of business-ese and jargon'
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Again ppl around me especially when I call someone, they would ask or say, what is this regards to...Are you sure they're both incorrect?
People will SAY most anything, but when in writing, it is incorrect.