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Please let me know if in the end of one's mail one can use these expressions

1. Thanks and Regards,

ABC.

2. Thanks and Best Regards,

ABC

I think:

Writing "Best Regards" is alike greeting. It is not amalgamated with "Thanks". Everyday I rcv. a few e-mails from client side; g'nally frm US or S'pore. What I've observed is that either they write "Best Regards" or they write "Thanks". Have rarely seen where both of them are mentioned. Therefore, I'm telling u this frm logical as well empirical view.

Please enlighten me.

Regards,

Saurabh
Hi, Saurabh--

These closings are informal, so there is considerable latitude as to what is acceptable. As you say, 'thanks' or 'best regards' or just 'regards' alone is quite sufficient, but there is no rule against using a combination if the writer chooses to do so.
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I think:

Writing "Best Regards" is alike greeting. It is not amalgamated with "Thanks". Everyday I rcv. a few e-mails from client side; g'nally frm US or S'pore. What I've observed is that either they write "Best Regards" or they write "Thanks". Have rarely seen where both of them are mentioned. Therefore, I'm telling u this frm logical as well empirical view.

Please enlighten me.
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 In some situations I like to just use "Best" instead of "Best regards".
"Best" what? It just seems so unfinished.

Is is appropriate to close with "Best" or "Thanks and Best?"

What is the answer?
Is it appropriate to close with "Best" -- Yes, this is casual and common; I use it frequently.
or "Thanks and Best"?-- No, this is odd; I have never seen it.
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So, if I understand correctly, using "Best" with no other works (i.e. Best regards, wishes, etc.) is acceptable?

Thanks for your input.
using "Best" with no other works (i.e. Best regards, wishes, etc.) is acceptable?-- Yes indeed, though it is informal.
Some people even use BR instead of Best Regards. I personally use "Thanks and Regards", but tend to move to simple Regards.
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