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The article, titled "PM Lee's wife Ho Ching weirdly shares article on cutting ties with family members", had quoted a Facebook post by PM Lee's sister, Dr Lee Wei Ling.

Is the comma after "article" required?

Thanks!
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tamguatlayIs the comma after "article" required?

Yes. It is the partner of the comma after "members". The phrase "PM Lee's wife Ho Ching weirdly shares article on cutting ties with family members" is parenthetical, and that requires it be set off with commas. It is truly parenthetical because the meaning of the sentence is that the article under consideration had quoted something, not that the article with that title had. That it had a particular title has no bearing on the main point. The title is extra information.

Comments  
anonymousThe phrase "PM Lee's wife

That should be "titled 'PM Lee's wife …."