What does "the most of it " mean?

E.g.: "The brush with death I had maybe had the biggest impact of all," Clinton recalled. "I realized that one more time I've been given another chance, and I wanted to make the most of it."

What about " the best of me"?
to "make the most of" something means to get the greatest possible benefit from it, to use it to the greatest possible advantage.

"the best of me" is hard to tell without context - "to get the best of someone" means "to defeat" -- "His exhaustion finally got the best of him and he fell asleep at his desk." Is this the meaning you are looking for?
Thank you very much.