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We have to study and know the nuts and bolts of the new machine before operating it.

Please check it.

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We have to read the owner's manual for the new machine before operating it.

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kumenglish

We have to study and know the nuts and bolts of the new machine before operating it.

I would not use two verbs in a row like that.

It's slightly problematic that the use of 'nuts and bolts' in your sentence is a bit ambiguous between the literal and the figurative because machines do have literal nuts and bolts.

More examples:

Literal use.
Nuts and bolts and paint thinners filled the closets.
Where else can you buy the nuts and bolts you need for your water heater?
Nuts and bolts had become detached, and all three stretcher bars had snapped.

Figurative use. (nuts and bolts = details)
Collins opened up about the nuts and bolts of the decision-making process.
Show me the school where the kids are learning the nuts and bolts of grammar.
What interests Stein is the nuts and bolts of legal practice, and few do it better.

CJ