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(If you don't know immunology, please give a reply on grammar)

Context:

Email Removed"> The increased recognition of the role of B cells in autoimmunity has led to renewed interest in the checkpoints that govern B cell tolerance, identifiable as ‘central’ when established in the bone marrow and ‘peripheral’ after B cells have exited to the periphery. Genetically determined defects that have an impact in either site can result in malfunctioning B cells and/or the accumulation of autoreactive B cells in the blood (Eric Meffre Yale University, New Haven, CT).
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When established = when the checkpoints were established? -- No; B-cell tolerance.
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Besides, does "central" refer to "central checkpoints" and "peripheral" "peripheral checkpoints"?
Yes, they seem to.
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