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Any advice greatly appreciated. I always get them mixed up.

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First, please check any good dictionary. If you still have questions, please get back.

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Effect is a noun.

Remember the phrase "cause and effect" or sentences like
This medication has some bad side effects.
I love the special effects in Star Wars.

Affect is a verb.

So many people are affected by the pandemic.

You can read more here:

https://dictionary.cambridge.org/grammar/british-grammar/affect-or-effect

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Comments  

I don't think there is a good mnemonic for that. Both words can be either a noun or a verb, and the meanings are somewhat similar. You just have to study and memorize.

 AlpheccaStars's reply was promoted to an answer.
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